Friday, March 14, 2014

Another shocking news for today, a postdoc died....

Heard from my college, a postdoc was died last night in the building few hundreds meters away from mine.....
Until now it said it was related chemical, further information will come late...

I thought bomb attack is far from me, it seems not

Just saw the news police arrested two people who planned to bomb attach the university.....

what's wrong with the world.

http://www.helsinkitimes.fi/finland/finland-news/domestic/9811-iltalehti-two-suspected-of-planning-a-bomb-attack-on-university-of-helsinki.html

Friday, March 7, 2014

治疗hiv新方法初次尝试

首次通过编辑基因来处理hiv。
http://dx.doi.org/10.1038/nature.2014.14813

Thursday, March 6, 2014

Call for copyright to move with the times-from research professional

Call for copyright to move with the times

Academics want EU-wide permission to mine data
Special provisions are urgently needed to stop copyright laws from hampering research activities, according to universities, libraries and funders.
Academic institutions say their staff must be free to carry out text and data mining, which involve using computer programmes to trawl through and analyse vast amounts of information from scientific papers. Such use is restricted by EU copyright legislation, but that could be about to change as the European Commission has launched a consultation to review the laws.
In consultation responses seen by Research Europe, several groups are calling for EU-wide exemptions to copyright for research purposes, on the basis that the regulations are stifling scientific and economic competitiveness. “We are very worried about this,” says Kurt Deketelaere, secretary-general of the League of European Research Universities.
Interest in computer-based mining techniques is growing among researchers as the volume of papers accessible online increases and better analytical technologies become available. But the respondents say that EU copyright laws have not kept up with this trend.
“Activities such as text and data mining are being hindered by a copyright framework that was not designed for the digital environment,” says the Association of European Research Libraries. “It is imperative that the framework is adapted to ensure that European innovation is competitive.”
The EU copyright directive allows member states to choose whether or not to implement a limit on non-commercial scientific research, meaning that laws vary widely. Many scientific publishers block the use of computer programmes for mining but grant permission on a case-by-case basis to academics who subscribe to their journals.
“What we really want is a clear, indisputable exemption for academic research, so there can be no discussion in the 28 member states or among different commercial players,” says Deketelaere.
“We think that content that people have already paid for should be free to read by computers as well as to read by eye,” says David Carr, a policy adviser at the Wellcome Trust, a UK-based medical research charity. The trust estimates that, under a licensing approach, a researcher wishing to mine 8,000 articles could spend up to 60 per cent of a working year—at a cost of €22,000—gaining permission from the articles’ publishers. “If researchers have to negotiate access to content on a journal-by-journal basis, it rapidly becomes unworkable,” says Carr.
Scientific groups are concerned that the Commission may only be considering a revision of the licensing procedures for text and data mining, rather than a fundamental law change. However, Pierre Delsaux, deputy director-general at the Directorate-General for Internal Market and Services, which oversees the consultation, refutes the idea that the outcome of the review is predetermined. “We have held the consultation to have a real debate,” he says, adding that the ability of the creative industries, including publishing, to remain economically viable must be taken into account.
In response to researchers’ demands, some publishers have started to make concessions. In January, Elsevier announced plans to allow text mining by subscribers on its ScienceDirect database. But the system contains restrictions on the amount of text that can be published, which some researchers object to.
The consultation was due to close on 5 March and the Commission intends to produce a white paper based on the outcome, after which it will begin discussions on future legislation. “Whatever we propose will be very difficult to negotiate,” says Delsaux. “There are a lot of interests at stake and it will be a lengthy process.”
But Deketelaere warns that if no exemption is made for academic research, this will be “the beginning of the war” between publishers and universities. “Everything up until now on open access is peanuts compared with this,” he says.
- See more at: http://www.researchprofessional.com/0/rr/news/europe/universities/2014/3/call-for-copyright-to-move-with-the-times.html#sthash.VggPj4qA.dpuf

Call for copyright to move with the times-from research professional

Call for copyright to move with the times

Academics want EU-wide permission to mine data
Special provisions are urgently needed to stop copyright laws from hampering research activities, according to universities, libraries and funders.
Academic institutions say their staff must be free to carry out text and data mining, which involve using computer programmes to trawl through and analyse vast amounts of information from scientific papers. Such use is restricted by EU copyright legislation, but that could be about to change as the European Commission has launched a consultation to review the laws.
In consultation responses seen by Research Europe, several groups are calling for EU-wide exemptions to copyright for research purposes, on the basis that the regulations are stifling scientific and economic competitiveness. “We are very worried about this,” says Kurt Deketelaere, secretary-general of the League of European Research Universities.
Interest in computer-based mining techniques is growing among researchers as the volume of papers accessible online increases and better analytical technologies become available. But the respondents say that EU copyright laws have not kept up with this trend.
“Activities such as text and data mining are being hindered by a copyright framework that was not designed for the digital environment,” says the Association of European Research Libraries. “It is imperative that the framework is adapted to ensure that European innovation is competitive.”
The EU copyright directive allows member states to choose whether or not to implement a limit on non-commercial scientific research, meaning that laws vary widely. Many scientific publishers block the use of computer programmes for mining but grant permission on a case-by-case basis to academics who subscribe to their journals.
“What we really want is a clear, indisputable exemption for academic research, so there can be no discussion in the 28 member states or among different commercial players,” says Deketelaere.
“We think that content that people have already paid for should be free to read by computers as well as to read by eye,” says David Carr, a policy adviser at the Wellcome Trust, a UK-based medical research charity. The trust estimates that, under a licensing approach, a researcher wishing to mine 8,000 articles could spend up to 60 per cent of a working year—at a cost of €22,000—gaining permission from the articles’ publishers. “If researchers have to negotiate access to content on a journal-by-journal basis, it rapidly becomes unworkable,” says Carr.
Scientific groups are concerned that the Commission may only be considering a revision of the licensing procedures for text and data mining, rather than a fundamental law change. However, Pierre Delsaux, deputy director-general at the Directorate-General for Internal Market and Services, which oversees the consultation, refutes the idea that the outcome of the review is predetermined. “We have held the consultation to have a real debate,” he says, adding that the ability of the creative industries, including publishing, to remain economically viable must be taken into account.
In response to researchers’ demands, some publishers have started to make concessions. In January, Elsevier announced plans to allow text mining by subscribers on its ScienceDirect database. But the system contains restrictions on the amount of text that can be published, which some researchers object to.
The consultation was due to close on 5 March and the Commission intends to produce a white paper based on the outcome, after which it will begin discussions on future legislation. “Whatever we propose will be very difficult to negotiate,” says Delsaux. “There are a lot of interests at stake and it will be a lengthy process.”
But Deketelaere warns that if no exemption is made for academic research, this will be “the beginning of the war” between publishers and universities. “Everything up until now on open access is peanuts compared with this,” he says.
- See more at: http://www.researchprofessional.com/0/rr/news/europe/universities/2014/3/call-for-copyright-to-move-with-the-times.html#sthash.VggPj4qA.dpuf

Wednesday, March 5, 2014

Coffee could help memory

Just hears the news from voa,they said the research showed coffee could increase the ability to memorize, but also increase nervous .

Tuesday, March 4, 2014

giant virus is coming back

latest news from nature.

scientist researchers have found a giant virus from 30000 years old ice, and this giant virus still infectious.
learn more: find more information here

Nature:    
doi:10.1038/nature.2014.14801

Sunday, March 2, 2014

climate change-what can we do?

what could we do with the climate change ? could we stop it ? i am not in this area. but it is hot topic nowadays.
 for me i could feel the environment around me is changing, comparing with the memo ten years ago..
in my home town, i have not seen snowing for many years, the rain is also less and less, especially recent few years.
few days ago, have read one paper from nature climate, the authors have utilized earth system model to see the effects of different method for climate changing. it seems like the methods have little effect on climate change if i did't understood wrongly.
i am thinking whether we could stop the climate changing or we just could slow down the changing process?

the most important thing, we should try our best to have better living environment, good water, air.....

fake papers-more are found

it is sad to read this news for all scientist, but we could not avoid it and have to face the problem. what is the reason for producing these non-sense papers.

According to recent news from nature, there're about 120 are found as fake paper, and most of them from china. most of these paper are generalized by a software called scigen.

there are several things we should think about,
1, why some scientist willing to produce such fake paper?
2, how these fake paper pass the examination of peer reviews?
3, what could we do to improve such problem?

we should re-think the publishing systems. not only you, me, but also the government, publishers, and reviewers....

original news could be found in the following link:
http://www.nature.com/news/publishers-withdraw-more-than-120-gibberish-papers-1.14763

Thursday, February 27, 2014

Field Virology 6th available

Fields Virology is the authoritative reference book for virology, providing definitive coverage of all aspects of virology, including thorough coverage of virus biology as well as replication and medical aspects of specific virus families.  With the regular outbreaks of influenza, noroviruses as well as other emerging and re-emerging viruses it is essential to have the most up-to-date information available.
With this Sixth Edition, all chapters have been completely updated, an important new emphasis has been placed on virus discovery and emerging viruses. Viruses associated with cancer, including the new human polyomaviruses, are highlighted in this Sixth Edition and new chapters have been added on circoviruses and mimiviruses. 
While the main focus of this edition continues to be on viruses, information on prions and the infectious spongiform encephalopathies are also included.


FEATURES• 2-volume set
• Full color throughout with over 1,000 illustrations in total and most chapters provide key figures for use as lecture slides
• Online companion website with fully searchable text, all references linked to PubMed and additional material not found in the print for access to content anytime
• New coverage of emerging and viruses, including those causing influenza and HIV
• Updated coverage of viruses and cancer
• Coverage includes virus structure, virus entry, replication, and assembly, virus-host cell interactions, host immune responses and vaccines, antiviral therapeutics, virus evolution and immunization
• Thorough coverage of all viruses of medical importance, including both basic science and clinical features
• New chapters on circoviruses and mimiviruses and a new section on Chikungunya virus have been added
• Important advances in antivirals, including new HCV protease inhibitors and HIV integrate inhibitors

http://www.lww.com/webapp/wcs/stores/servlet/product_Fields-Virology_11851_-1_9012053_Prod-9781451105636?cm_sp=PE-MED-InfectiousDiseases-_-Banner-InfectiousDiseases-_-Left-NoPromo-FieldsVirology-NewEdition

Wednesday, February 26, 2014

plant factory-producing medicine

制造蛾信息素的植物工厂
蛾类通过信息素的交流来寻找配偶,人工合成的信息素通常用来监控或者干扰害虫的信息素交流。该研究以本生烟作为工厂通过瞬时表达最多四个编码基因来连续合成途径,我们生产出两种蛾类特异的多组分性信息素。来自经过遗传修饰植物的脂肪醇片段加速了属于小巢蛾Yponomeuta evonymellaY. padella性信息素的模拟过程。这些混合物非常有效和特异的诱捕雄性蛾,这说明符合常规的性信息素。我们的长期目标是在遗传修饰的植物中设计量身定做的任何蛾类信息素。这种半合成制备性信息素是一个生产中等至大规模生产高质量低污染的非常新颖和非常划算的方式



Moths depend on pheromone communication for mate finding and synthetic pheromones are used for monitoring or disruption of pheromone communication in pest insects. Here we produce moth sex pheromone, using Nicotiana benthamiana as a plant factory, by transient expression of up to four genes coding for consecutive biosynthetic steps. We specifically produce multicomponent sex pheromones for two species. The fatty alcohol fractions from the genetically modified plants are acetylated to mimic the respective sex pheromones of the small ermine moths Yponomeuta evonymella and Y. padella. These mixtures are very efficient and specific for trapping of male moths, matching the activity of conventionally produced pheromones. Our long-term vision is to design tailor-made production of any moth pheromone component in genetically modified plants. Such semisynthetic preparation of sex pheromones is a novel and cost-effective way of producing moderate to large quantities of pheromones with high purity and a minimum of hazardous waste.

http://www.nature.com/ncomms/2014/140225/ncomms4353/full/ncomms4353.html

Sunday, February 23, 2014

Friday, February 21, 2014

Fifth edition Plant Virology

The seminal text Plant Virology is now in its fifth edition. It has been 10 years since the publication of the fourth edition, during which there has been an explosion of conceptual and factual advances. 

The fifth edition of Plant Virology updates and revises many details of the previous edition while retaining the important earlier results that constitute the field's conceptual foundation. Revamped art, along with fully updated references and increased focus on molecular biology, transgenic resistance, aphid transmission, and new, cutting-edge topics, bring the volume up to date and maintain its value as an essential reference for researchers and students in the field.


  • Thumbnail sketches of each genera and family groups
  • Genome maps of all genera for which they are known
  • Genetic engineered resistance strategies for virus disease control
  • Latest understanding of virus interactions with plants, including gene silencing
  • Interactions between viruses and insect, fungal, and nematode vectors
  • Contains over 300 full-color illustration

Address:

http://www.sciencedirect.com/science/book/9780123848710