Vector NTI® software is a completely integrated suite of sequence analysis and design tools that help you manage, view, analyze, transform, share, and publicize diverse types of molecular biology data, all within one graphically rich analysis environment. Vector NTI®Software allows you to:
- Curate—store and manage collections, visualize maps, and search sequences
- Discover—analyze, compare, and contrast sequences
- Design—cloning strategy; primers for PCR, cloning, and
resequencing; and gel simulations of sequences - Confirm—contig assembly, sequence validation, and
literature validation
What is Vector NTI Advance® Software?
Vector NTI Advance® 11.5—The Industry Standard for Sequence Analysis
Vector NTI Advance® offers unparalleled, multi-modular, integrated sequence analysis and data management tools. The software contains a comprehensive set of data analysis and management tools, implemented across five application modules.
For Mac users, Vector NTI Advance® 11.5 can be run using Parallels Desktop® and on Windows® XP Pro on Intel®-based Macs. For PC users, Vector NTI Advance® runs on Windows® 7, Windows Vista®, and XP Pro operating systems, including in Japanese language editions.
Vector NTI®
ContigExpress®
BioAnnotator™
| AlignX®
GenomBench™
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For a detailed summary of Vector NTI Advance® key applications, click here.
 | The Vector NTI® multi-modular, integrated sequence analysis and data management tools enable seamless workflows. |
Cloning Tools
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Clone2Seq™ is designed for those who already know how they wish to recombine two restriction fragments, e.g., cloning a BamHI-EcoRI insert into an appropriately digested vector. The interface makes it easy to select molecules and fragments for cloning, to modify fragment ends for compatibility (if necessary), and to create the desired recombinant, whether circular or linear. Despite the simplicity of the workflow, Clone2Seq™ retains all the power of the cloning functionality in Vector NTI Advance®, including our renowned graphical map creation and parent-descendant lineage tracking.
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VectorSelector™ enables you to search for cloning vectors based on eight different criteria such as one or two different restriction sites, with annotated coding DNA sequence (CDS) features that confer drug resistance, by linear or circular form and by having specific attB sites that are used in Gateway® cloning. Results are captured in a spreadsheet-style format, and any group of results can be saved to a subset in the Local Database. Any individual search result can be opened in the Molecule Viewer or even sent to Clone2Seq™ for use in a rapid cloning experiment.
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 | Gene Synthesis with ReGENerator™ allows you to design specific DNAs in silico. Start with your protein sequence, and if required, mutate it by substituting, adding, or deleting amino acids by simply typing in new resides. Any number and type of mutation can be made in this step. Choose a codon-usage table that best reflects your experimental expression system, and ReGENerator™ will calculate a DNA sequence that encodes your desired protein. You can add any number of flanking sequences to the 5′ and 3′ ends of the newly-created DNA—such as restriction sites, Gateway® cloning sites, and expression or purification tags. With the simple click of a button you'll be directed to the GENEART website for the best products and services in gene synthesis. |
Robust Data Management and Usability
Vector NTI Advance® software includes the Vector NTI® Local Database, to help you store and manage many types of molecular biology data. The local database allows sophisticated levels of integration of analysis tools and raw data. You can also store the results of many analyses in the database as well.
Vector NTI Advance® uses open file format to manage the molecule data, meaning all data files for storage and export are all readable by a text editor (e.g., Microsoft Windows® Notepad). Unlike other programs of this type that use a proprietary data format that locks users into a single software solution, Vector NTI Advance® allows the data files to be openly exchangeable.
In a world with growing global collaboration, we believe open data exchange is critical for success. Even if you cease using Vector NTI®, you are assured that your data remains accessible to you and can be imported to a different software program of your choice.
Find out how easy it is using Notepad to take a look at the sequences and molecule descriptions in the database folder of Vector NTI (C:\Vector NTI Database) by opening up the .mol, .seq, and .ma4 files upon which the database is built.
Find out how easy it is using Notepad to take a look at the sequences and molecule descriptions in the database folder of Vector NTI (C:\Vector NTI Database) by opening up the .mol, .seq, and .ma4 files upon which the database is built.
Vector NTI® Express
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Completely redesigned to be faster, more intuitive and with a dedicated Mac OS® X version Vector NTI® Express Software retains the core, trusted tools of Vector NTI Advance®Software with a brand new interface.
Built on a new platform, Vector NTI® Express Software supports the future of bioinformatics and synthetic biology with a plug-in architecture to consistently deliver new tools and functionality.
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What's New in Vector NTI® Express Software
Performing multiple sequence alignments with the new interface of Vector NTI® Express
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- Brand New Interface. Find and use tools quickly and easily with an intuitive and streamlined interface. Vector NTI® Express introduces an internet browser-like functionality to switch between projects in a tabular view.
- Dedicated Mac OS® X Support. Vector NTI® Express runs on Mac OS® X without the need for emulation solutions. Windows® 7 and Windows® XP operating systems are also supported.
- Plug-In Architecture. New Bioinformatics tools from Life Technologies will be delivered seamlessly through automatic updates to the existing software. Vector NTI® Express will check for these new tools automatically in addition to refinements to existing tools so you can have full confidence your software is up to date. Vector NTI® Expresswill check for these new tools automatically in addition to refinements to existing tools so you can have full confidence your software is up to date.
Prescribed workflows make projects such as Contig-Assembly and Gateway®cloning easy to perform, step-by-step.
Click to enlarge and see a full-screen view.
- Prescribed Workflows. Projects such as Contig-assembly and Gateway® and TOPO® cloning are now performed in a step-by-step workflow. Quickly identify suitable Gateway® or TOPO® vectors from your library and build your clones with ease.
- Next-Generation Sequencing (NGS) Support. Bam File outputs from NGS platforms such as Ion Torrent PGM™, SOLiD®, and Illumina®HiSeq® platforms that have been processed into FASTA File format (we recommend tools such as SAM tools and Picard) can be read into Vector NTI® Express for analysis.
- EMBOSS Algorithms. Standards-Based Bioinformatics Algorithms, Import Support for Analysis File Types (BED, GFF, GTF), Compare Annotation on a Genome—Multi-Track Analysis (Gene, Promoter, Multiple Splice Variants, Transcript, Protein, and Terminator), and intersections to create new annotations.
- Molecule Relationships. New tools for studying DNA-protein relationships, including translation, reverse-translation, and codon optimization.
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